Capegard (Capecitabine)



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Capegard (Capecitabine) is a cancer drug which is indicated for colorectal cancer and metastatic breast cancer. Its mechanism of action involves working within the cancer cells to affect their growth.

Brand Name : Capegard
Active Ingredients : Capecitabine
Manufacturer : Cipla
Country of Origin : India
Intended Patient : Unisex

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Capegard (Capecitabine) is a cancer drug which is indicated for colorectal cancer and metastatic breast cancer. Its mechanism of action involves working within the cancer cells to affect their growth. This chemotherapy drug is used for adjuvant treatment for patients affected by Dukes` C colon cancer and as a first line therapy for metastatic colorectal cancer. When used for breast cancer, it may either be used together with other medicines (such as docetaxel) or on its own.

This medicine is classified as an antimetabolite, and it is a prodrug. This means that it is converted into 5-fluorouracil (5-FU) by enzymes in the body. Following this, healthy and tumor cells further convert it into other metabolites (FdUMP and FUTP) that interfere with the process in which DNA, RNA and protein are synthesized. Without DNA, the division and growth of cancerous cells is affected and they are unable to grow properly. This results in their eventual death, allowing for the size of the tumor to be reduced and the growth of the cancer cells stopped.

In addition to attacking cancer cells, this medicine may also affect healthy cells. This could result to side effects. However, due to the fact that the conversion of the prodrug into its active form (5-HU) usually only occurs in the cancerous cells, the risk of side effects is less when compared to other cancer medicines. A significant amount of medical research has been conducted which focused on this medicine`s effects if used for other conditions. These studies examined its effects if used for gastric, pancreatic or esophageal cancer.

Dosage and Administration

Capegard (Capecitabine) 500mg tablets are taken by mouth. The dosage needed will be decided upon by the physician in charge of medical care and the patient will need close medical supervision throughout the entire duration of treatment. These tablets need to be swallowed whole alongside a full glass of water within 30 minutes of consuming a meal.

If used for monotherapy, it is possible that treatment will consist of twice daily dosing for a period of 2 weeks, after which a 1 week break will be advised. This 3 week cycle may need to be repeated as necessary in accordance with the instructions of your physician. Patients with renal impairment may need a lower dosage, and it is also important to note that the exact dosage needed may be individualized by the physician based on other factors.

Side effects

Treatment with the chemotherapy agent Capegard (Capecitabine) can cause side effects. Ensure that you report all reactions to your physician. Possible reactions include:

  • Pruritis
  • Hair loss
  • Low appetite
  • Irritated eyes
  • Altered taste sensation

Certain adverse events are serious and you will need immediate treatment if they occur. Consult your physician straight away if you suffer from diarrhea, nausea, inflammation of the feet and hands, pain and sores on the mouth, symptoms of an infection or any other severe reactions that have not been referenced in this paragraph.


Capegard (Capecitabine) could cause a serious reaction in patients who are taking anticoagulant medicines (also called blood thinners), which may result in bleeding which has the potential to be fatal. Your physician will discuss this with you before commencing treatment.

This medicine could make you more susceptible to certain illnesses, due to it reducing your body`s ability to defend itself against infections. Stay away from people with colds, flu or other infections whenever possible and maintain personal hygiene.

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